|Pulse Wave Velocity distribution in a cohort study - from Arterial Stiffness to Early Vascular Ageing (EVA)
Pedro G. Cunha (1)(2)(3), Jorge Cotter(1)(2)(3), Pedro Oliveira(4), Isabel Vila(1), Pierre Boutouyrie(5), Stéphane Laurent(5), Peter M Nilsson(6), Angelo Scuteri(7), Nuno Sousa(2)(3)
Methodology of Pulse Wave Velocity measurement and standardization
All PWV values were obtained using the subtracted distance method for path length; for standardization and comparison purposes they were uniformly transformed to the value obtained using the direct path length (also measured during patient evaluation), through the equation proposed by Boutouyrie et al (16):
Xdirect = 0.45 x Distancesubtracted + 0.21 × Height + 0.08 (m)
The PWV values obtained using the calculated direct path length were normalized (multiplied by 0.8). In a separate analysis (not shown), both PWV measures (direct path vs. subtracted path length) were highly correlated (r = 0.96) and using an Bland-Altman plot methodology of comparison evidenced no substantial difference (if anything, the direct path method would, in average, underestimate PWV values by 0.2 m/s). Using the normalized direct distance calculated PWV will now allow us to compare the obtained values with the ones published as European reference (16).
Acknowledgments. The authors wish to show their acknowledgment to the following institutions and departments who collaborated in this project: Agrupamento de Centros de Saúde de Guimarães e Vizela, Serviço de Patologia Clínica do Centro Hospitalar do Alto Ave, Centro de Saúde da Amorosa, USF Afonso Henriques, USF Ara Trajano, USF Duo Vida, USF Novos Rumos, USF de Pevidém, USF Physis, USF de Ponte, USF de Ronfe, USF S. Nicolau, USF de S. Torcato, USF de Serzedelo e USF Vimaranes. A special word is addressed to thank all the physicians working in those different Primary Health Care Community Centers, whose work enrolling subjects was vital to the successful prosecution of our goals.
The Guimarães Study Group is also composed by the following researchers, who were involved in data collection: Helena Sarmento, Gloria Alves, Sara Freitas, Ana Sofia Alves, Sofia Gomes, Marta Gonçalves, Rui Fernandes, António Pedro Fonte, José Miguel Sá, Clarisse Neves, Andreia Sampaio, Cristina Cunha, Sílvia Sousa, Filipe Gonçalves, Joana Malheiro, João Silva, Carlos Fernandes, Estefânia Bustabad, Laura Castro, Nuna Vieira, Filipa Ramos, Ana Catarina Marques, Joana Monteiro, Ana Sofia Silva, Margarida Rocha, Mafalda Jordão Abreu, Margarida Dias, Magda Fernandes, Paula Felgueiras, Francisca Castro, Vânia Gomes, Ana Luísa Novo, Carla Pereira, Ana Cristina Ramalho, Fernando Esculcas, Dina Fernandes, Ricardo Rodrigues, Rafael Velho, Diana Coimbra, Joana Pimenta, João Pedro Teixeira, Ana Luísa Neves, Joana Leitão, Sara Pereira, Carla Ferreira, Clarinda Neves, Samuel Pedreira, Pedro Neves, Elisabete Lima, Carla Mendes, Orlanda Barbosa, Ana Catarina Martins, Célia Lemos, Eduarda Macedo, Sílvia Azevedo, Ana Rita Ribeiro, Elsa Salgado, Joana Dias, Eduarda Piairo, Marisa Carneiro, Ismael Costa, Lucília Miranda, Ana João Gonçalves, Natália Rodrigues, Manuela Morais, Rosário Santos, Odete Rodrigues, Alexandra Barreira, Ana Rita Romano, Catarina Marques, Fernanda Marisa Santos, Sónia Coelho Pereira, Elisabete Pinto Teixeira, Joana Andrade Pinto
Figure SM1 - Logistic curves for the development of PWV>10m/s as a function of age and BP class for men and women without Diabetes, and with normal Heart Rate < 75 bpm